Cajetan was ordained priest in 1516. He left the papal court and dedicated himself entirely to the service of the Lord. With his own hands he cared for the sick. Such zeal did he show for the salvation of his fellowmen that he was surnamed the "huntsman for souls."
St. Cajetan often prayed eight hours daily. While attending the Christmas celebration at St. Mary of the Crib, he is said to have been given the grace of receiving from Mary the Child Jesus into his arms.
St. Cajetan founded in 1524 a community of priests who were to lead an apostolic life. They were to look with disdain all earthly belongings, to accept no salaries from the faithful; only from that which was freely donated were they allowed to retain the means of livelihood.
He founded a bank to help the poor and offer an alternative to usurers (loan sharks). It later became the Bank of Naples. His concern for the unemployed, giving them the necessary financial help in their time of need, made him their patron. His feast is celebrated on August 7.